Cloxacillin is a semisynthetic β-lactamase inhibitor.
| Cas No. | 642-78-4 |
| 别名 | 氯唑西林钠 |
| Canonical SMILES | CC1(C)[C@H](C([O-])=O)N2C([C@@H](NC(C3=C(C)ON=C3C4=CC=CC=C4Cl)=O)[C@@]2([H])S1)=O.[Na+] |
| 分子式 | C19H17ClN3O5S•Na |
| 分子量 | 457.9 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 16 mg/mL,Ethanol: 2 mg/mL,PBS (pH 7.2): 10 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cloxacillin is a semisynthetic β-lactamase inhibitor. It binds to and inactivates penicillin-binding proteins that cross-link peptidoglycans, which are structural components of bacterial cell walls. In vitro, addition of cloxacillin (0.50 μg/ml) almost completely inhibits B. megaterium growth. Cloxacillin inhibits recombinant type Ib penicillinase, P. vulgaris cephalosporinase, and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively) as well as S. aureus and S. epidermidis growth (MICs = 0.2 and 0.2 μg/ml, respectively). In vitro, addition of cloxacillin (0.50 μg/ml) almost completely inhibits B. megaterium growth. Formulations containing cloxacillin have been used to treat infections caused by methicillin-sensitive staphylococci. |
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