Epiberberine

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Epiberberine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6873-09-2

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品名称

表小檗碱

产品介绍

Epiberberine 是从黄连中得到的生物碱，为有效的AChE和BChE抑制剂，和非竞争性的BACE1抑制剂，IC₅₀值分别为 1.07，6.03 和 8.55 μM。Epiberberine 具有抗氧化作用，能够清除 ONOO^-(IC₅₀，16.83 μM)，可用于阿尔滋海默症和糖尿病的研究。在 3T3-L1 细胞分化早期，Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。

生物活性

Epiberberine is an alkaloid isolated fromCoptis chinensis, acts as a potentAChEandBChEinhibitor, and a non-competitiveBACE1inhibitor, withIC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO^-scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease^[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways^[2]. Epiberberinecan be used for the research of diabetic disease^[3].

IC₅₀& Target

BACE1

AChE

BChE

体外研究
(In Vitro)

Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC₅₀of 52.8 μM^[2].
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation^[2].
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner^[3].

体内研究
(In Vivo)

Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice^[3].

分子量

336.36

性状

Solid

Formula

C₂₀H₁₈NO₄⁺

CAS 号

6873-09-2

中文名称

表小檗碱

结构分类

Alkaloids
Isoquinoline Alkaloids

来源

Plants
Ranunculaceae
Coptis chinensisFranch.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 3.33 mg/mL(9.90 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.9730 mL	14.8650 mL	29.7301 mL
5 mM	0.5946 mL	2.9730 mL	5.9460 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。