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Lutein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lutein图片
CAS NO:127-40-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
20mg电议
50mg电议
100mg电议

产品名称
Xanthophyll
产品介绍
Lutein (Xanthophyll) 是一种类胡萝卜素,具有抗炎作用。Lutein 具有多种有益作用,尤其是对眼睛健康。Lutein 通过影响活性氧 (ROS) 发挥抗炎、抗氧化酶、抗凋亡 (apoptosis) 等生物活性。Lutein 能够到达大脑,显示出抗抑郁类和神经保护作用。Lutein 具有口服活性。
生物活性

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects onreactive oxygen species(ROS)[2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4].

体外研究
(In Vitro)

Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].

体内研究
(In Vivo)

Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats[3].
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) preventsCorticosterone(HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].

Animal Model:Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3]
Dosage:40, 80 and 160 mg/kg
Administration:In diet for 5 weeks
Result:Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
Animal Model:Male Swiss mice, chronicCorticosterone(HY-B1618) model of depression[4]
Dosage:0.1, 1 and 10 mg/kg
Administration:Oral administration, once or daily for 7 and 21 days
Result:Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed byCorticosterone(HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
分子量

568.87

性状

Solid

Formula

C40H56O2

CAS 号

127-40-2

中文名称

叶黄素

结构分类
  • Terpenoids
  • Diterpenoids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 25 mg/mL(43.95 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.7579 mL8.7894 mL17.5787 mL
5 mM0.3516 mL1.7579 mL3.5157 mL
10 mM0.1758 mL0.8789 mL1.7579 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。