CAS NO: | 1222998-36-8 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Torin 1 is a potent inhibitor ofmTORwith anIC50of 3 nM. Torin 1 inhibits bothmTORC1/2complexes withIC50values between 2 and 10 nM. Torin 1 is an effective inducer ofautophagy. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs[1]. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK[2]. | ||||||||||||||||
体内研究 (In Vivo) | Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues[2]. | ||||||||||||||||
分子量 | 607.62 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C35H28F3N5O2 | ||||||||||||||||
CAS 号 | 1222998-36-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 2 mg/mL(3.29 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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以下溶剂前显示的百
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