CAS NO: | 1221962-86-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | PS210 is a potent and selectivePDK1activator with aKdof 3 μM and targets the PIF-binding pocket ofPDK1. PS210 is inactive against other protein kinases, includingPDK1downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor ofPDK1, inhibiting the phosphorylation and activation of S6K[1][2]. | ||||||||||||||||
IC50& Target | Kd: 3 μM (PDK1)[2] | ||||||||||||||||
体外研究 (In Vitro) | When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation[1]. | ||||||||||||||||
分子量 | 380.31 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H15F3O5 | ||||||||||||||||
CAS 号 | 1221962-86-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(262.94 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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