CAS NO: | 1314883-11-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | MMV390048 is a representative of a new chemical class ofPlasmodiumPI4Kinhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site ofPlasmodiumPI4Kand does not bind to otherP. falciparumand human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 393.38 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H14F3N3O2S | ||||||||||||||||
CAS 号 | 1314883-11-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(254.21 mM;Need ultrasonic) 配制储备液
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