KDU731

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KDU731

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1610610-48-4

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

KDU731，具有口服活性的C. parvumPI4K抑制剂，阻断体内外隐孢子虫感染，IC₅₀值为 25 nM。KDU731 是研究隐孢子虫引起的腹泻的有望候选药物，具有广泛的安全性。

生物活性

KDU731, an orally activeC. parvumPI4Kinhibitor with anIC₅₀value of 25 nM, blocksCryptosporidiuminfectionin vitro and in vivo^[1]^[2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused byCryptosporidiumand meets a broad range of safety^[2].

IC₅₀& Target

PI4K

体内研究
(In Vivo)

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity againstCryptosporidiumin immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding^[2].
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool^[2].

Animal Model:	6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts^[1]
Dosage:	7 or 10 mg/kg
Administration:	Orally administration; 7 or 10 mg/kg; 16 days
Result:	Resulted in significant reduction of oocyst shedding.

Animal Model:	Neonatal calves with 5 x 10⁷oocysts^[1]
Dosage:	5 mg/kg
Administration:	Orally administration; 5 mg/kg; every 12 hours for 7 days
Result:	Resulted in significant reduction of oocyst shedding in treated calves in their stool.

分子量

396.40

性状

Solid

Formula

C₂₂H₁₆N₆O₂

CAS 号

1610610-48-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL(210.22 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.5227 mL	12.6135 mL	25.2270 mL
5 mM	0.5045 mL	2.5227 mL	5.0454 mL
10 mM	0.2523 mL	1.2614 mL	2.5227 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。