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MOMIPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MOMIPP图片
CAS NO:1363421-46-8
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
MOMIPP,一种巨胞饮作用的诱导剂,是一种PIKfyve抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。
生物活性

MOMIPP, a macropinocytosis inducer, is aPIKfyveinhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

体外研究
(In Vitro)

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 μM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].

Western Blot Analysis[2]

Cell Line:U251 cells
Concentration:10 μM
Incubation Time:4 h or 24 h
Result:Activated the JNK stress kinase pathway.
体内研究
(In Vivo)

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].

Animal Model:Athymic CrTac:NCR-Foxn1mice (female, 7-8 weeks)[2]
Dosage:80 mg/kg
Administration:i.p.; once daily; for 15 consecutive days
Result:Suppressed progression of intracerebral glioblastoma xenografts.
分子量

292.33

性状

Solid

Formula

C18H16N2O2

CAS 号

1363421-46-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 31.25 mg/mL(106.90 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.4208 mL17.1040 mL34.2079 mL
5 mM0.6842 mL3.4208 mL6.8416 mL
10 mM0.3421 mL1.7104 mL3.4208 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。