DA-PROTAC

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DA-PROTAC

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2488660-12-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

DA-PROTAC 是一种有效的铜离子转运蛋白Atox1和CCS的PROTAC降解剂。DA-PROTAC 可结合 Atox1 和 CCS 蛋白，而该复合物可结合 E3 连接酶，导致 Atox1 和 CCS 泛素化水平升高，并通过蛋白酶体途径降解 Atox1 和 CCS 蛋白。DA-PROTAC可用于三阴性乳腺癌研究。

生物活性

DA-PROTAC is a potentPROTACdegrader of copper ion-transport proteinsAtox1andCCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via theproteasomepathway. DA-PROTAC can be used for triple negative breastcancerresearch^[1].

IC₅₀& Target

VHL

体外研究
(In Vitro)

DA-PROTAC (0-1 μM, 24 h) can degrade Atox1 and CCS proteins rather than inhibit Atox1 and CCS activity^[1].
DA-PROTAC (5 μM, 24 h) inhibits the proliferation, migration and invasion of triple negative breast cancer cells (MDA-MB-231)^[1].
DA-PROTAC (10 μM, 48 h) inhibits the tumorigenic capacity of triple negative breast cancer cells (MDA-MB-231)^[1].
The targeting module of DA-PROTAC is a small molecule VHL ligand1 combined with E3 ligase^[1].

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	100 nM ,200 nM ,500 nM , and 1000 nM
Incubation Time:	24 h
Result:	Significantly reduced ATOX1 and CCS protein levels under 200nM, indicating that DA-PROTAC can degrade ATOX1 and CCS proteins.

分子量

1010.96

Formula

C₄₆H₅₀BrF₂N₇O₈S₂

CAS 号

2488660-12-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.