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JNJ-40411813(ADX-71149)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ-40411813(ADX-71149)图片
CAS NO:1127498-03-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
JNJ-40411813 (ADX-71149) (ADX-71149) 是一种新型的代谢型谷氨酸 2 受体 (mGlu2R) 正变构调节剂,EC50 为 147 nM。
Cas No.1127498-03-6
别名ADX-71149
Canonical SMILESO=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC
分子式C20H25ClN2O
分子量344.88
溶解度DMSO : 25 mg/mL (72.49 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

[1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.