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(+)-Cloprostenol(D-Cloprostenol)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(+)-Cloprostenol(D-Cloprostenol)图片
CAS NO:54276-21-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
(+)-氯前列醇 (D-Cloprostenol) 是一种前列腺素 F2α； (PGF2α) 类似物，对前列腺素受体显示选择性激动活性。
Cas No.54276-21-0
别名(+)-氯前列烯醇,D-Cloprostenol
Canonical SMILESOC(CCC/C=C\C[C@@H]1[C@H]([C@H](O)C[C@@H]1O)/C=C/[C@@H](O)COC2=CC(Cl)=CC=C2)=O
分子式C22H29ClO6
分子量424.92
溶解度DMSO: 100 mg/mL (235.34 mM); Ethanol: 50 mg/mL (117.67 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P< 0.05) and approximately 280 times more potent than PGE1 in inhibiting [3H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes[2].

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch[1].

[1]. Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21. [2]. Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8.