CAS NO: | 2349356-09-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BSJ-03-204 is aPROTACconnected by ligands forCereblonandCDK. BSJ-03-204 is a potent and selective Palbociclib-basedCDK4/6dual degrader (PROTAC), withIC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity[1]. | ||||||||||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | BSJ-03-204 (0.0001-100 μM; for 3 or 4 days) has potent anti-proliferative effects on MCL cell lines[1]. Cell Proliferation Assay[1]
Cell Cycle Analysis[1]
Western Blot Analysis[1]
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分子量 | 832.90 | ||||||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||||||
Formula | C43H48N10O8 | ||||||||||||||||||||||||
CAS 号 | 2349356-09-6 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(120.06 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |