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LH1307
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LH1307图片
CAS NO:2375720-38-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A PD-1/PD-L1 interaction inhibitor
Cas No.2375720-38-8
Canonical SMILESCC1=C(COC2=C(C)C=C(CNCCNC(C)=O)C(OCC3=CN=CC(C#N)=C3)=C2)C=CC=C1C4=C(C)C(COC5=CC(OCC6=CN=CC(C#N)=C6)=C(CNCCNC(C)=O)C=C5C)=CC=C4
分子式C54H58N8O6
分子量915.1
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays).

|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).