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N-methyl Mesoporphyrin IX
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-methyl Mesoporphyrin IX图片
CAS NO:142234-85-3
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
N-甲基中卟啉 IX (NMM) 是一种广泛使用的 G-四链体 DNA 特异性荧光结合剂，是监测 Aβ 纤颤的有效探针。
Cas No.142234-85-3
别名N-甲基中卟啉IX
化学名8,13-diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid
Canonical SMILESCC1=C2[NH]C(/C=C(C(CCC(O)=O)=C3C)\[N]=C3/C=C4[N](C)/C(C(C)=C\4CC)=C\C5=[N]/C(C(C)=C5CC)=C\2)=C1CCC(O)=O
分子式C35H40N4O4
分子量580.7
溶解度15mg/mL in DMSO, 20mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述
N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.[1] It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.[2] It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.[3] N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.[4]

Reference:
[1]. de Matteis, F., Gibbs, A.H., and Smith, A.G. Inhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effect. Biochem. J. 189(3), 645-648 (1980).
[2]. Ren, J., Qin, H., Wang, J., et al. Label-free detection of nucleic acids by turn-on and turn-off G-quadruplex-mediated fluorescence. Anal. Bioanal. Chem. 399(8), 2763-2770 (2011).
[3]. Li, M., Zhao, A., Ren, J., et al. N-Methyl mesoporphyrin IX as an effective probe for monitoring Alzheimer’s disease β-amyloid aggregation in living cells. ACS Chem. Neurosci. 8(6), 1299-1304 (2017).
[4]. Paramasivan, S., and Bolton, P.H. Mix and measure fluorescence screening for selective quadruplex binders. Nucleic Acids Res. 36(17), e106 (2008).