CAS NO: | 2378261-89-1 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | K-Rasligand-Linker Conjugate 6 incorporates a ligand forK-Rasrecruiting moiety, and aPROTAClinker, which recruitE3 ligases(such as VHL, CRBN,MDM2, and IAP).K-Rasligand-Linker Conjugate 6 can be used in the synthesis ofPROTACK-Ras Degrader-1 (HY-129523), which is potentPROTACK-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
体外研究 (In Vitro) | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
分子量 | 788.98 |
性状 | Oil |
Formula | C42H60N8O7 |
CAS 号 | 2378261-89-1 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |