CAS NO: | 895519-90-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Flumatinib (HHGV678) is an orally available, selective inhibitor ofBcr-Abl. Flumatinib inhibitsc-Abl,PDGFRβandc-KitwithIC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1]. | ||||||||||||||||
IC50& Target | IC50 Value: 1.2 nM (c-Abl); 307.6 nM(PDGFRβ); 2662 nM (c-Kit)[1]. | ||||||||||||||||
体外研究 (In Vitro) | Flumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 [1]. Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) [2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 562.59 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H29F3N8O | ||||||||||||||||
CAS 号 | 895519-90-1 | ||||||||||||||||
中文名称 | 氟马替尼 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(177.75 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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