DDR1-IN-1 dihydrochloride is a potent and selectiveDDR1receptor tyrosine kinaseinhibitor with anIC₅₀of 105 nM; 4-fold less potent forDDR2(IC₅₀= 413 nM)^[1].

DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC₅₀= 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC₅₀< 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture^[1].

625.51

C₃₀H₃₃Cl₂F₃N₄O₃

1780303-76-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.