tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with anIC₅₀of 0.33 μM.

IC50: 0.33 μM (HIPK2)^[1]

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC₅₀=0.33 μM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture^[1].

528.78

Solid

C₁₁H₃Br₄N₃O₂

1639895-85-4

Room temperature in continental US; may vary elsewhere.

DMSO : 20 mg/mL(37.82 mM;Need ultrasonic)

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