Super-TDU

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Super-TDU

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1599441-71-0

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议

产品介绍

Super-TDU 是一种特异性的YAP拮抗剂，可以靶向 YAP-TEAD 相互作用。Super-TDU 可以抑制胃癌小鼠模型的肿瘤生长。

生物活性

Super-TDU is a specificYAPantagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastriccancermouse model^[1].

体外研究
(In Vitro)

Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27^[1].

体内研究
(In Vivo)

Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice^[1].
Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t_1/2αof 0.78 hours and 0.82 hours; the C_maxof 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively^[1].

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	50 μg/kg or 500 μg/kg
Administration:	Intravenous Injection; per day
Result:	Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:	Intravenous Injection
Result:	The t_1/2αis 0.78 hours and 0.82 hours; the C_maxis 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

分子量

5279.94

性状

Solid

Formula

C₂₃₇H₃₇₀N₆₆O₆₉S

CAS 号

1599441-71-0

Sequence

Ser-Val-Asp-Asp-His-Phe-Ala-Lys-Ser-Leu-Gly-Asp-Thr-Trp-Leu-Gln-Ile-Gly-Gly-Ser-Gly-Asn-Pro-Lys-Thr-Ala-Asn-Val-Pro-Gln-Thr-Val-Pro-Met-Arg-Leu-Arg-Lys-Leu-Pro-Asp-Ser-Phe-Phe-Lys-Pro-Pro-Glu

Sequence Shortening

SVDDHFAKSLGDTWLQIGGSGNPKTANVPQTVPMRLRKLPDSFFKPPE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(9.47 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.1894 mL	0.9470 mL	1.8940 mL
5 mM	0.0379 mL	0.1894 mL	0.3788 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (4.73 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。