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Dexchlorpheniramine(maleate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dexchlorpheniramine(maleate)图片
CAS NO:2438-32-6
包装与价格：
包装价格(元)
500mg电议
1g电议

产品介绍
右氯苯那敏（马来酸盐）是一种抗组胺药，具有抗胆碱能特性，用于治疗过敏性疾病。
Cas No.2438-32-6
别名马来酸右氯苯那敏; S-(+)-Chlorpheniramine maleate salt
化学名γS-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate
Canonical SMILESClC(C=C1)=CC=C1[C@H](CCN(C)C)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O
分子式C16H19ClN2•C4H4O4
分子量390.9
溶解度Slightly Soluble in DMSO, DMF, Chloroform, Methanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro. [1] It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 &#181M. [2] Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 &#181M.[3] In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg.[4] Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.

Reference:
[1]. Shamsa, F., Ahmadiani, A., and Khosrokhavar, R. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J. Ethnopharmacol. 64(2), 161-166 (1999).
[2]. Holen, E., Elsayed, S., and Nyfors, A. The effect of H1 receptor antagonists on peripheral blood mononuclear cells, adenoid cells and primary cell lines. APMIS 103(2), 98-106 (1995).
[3]. Barnett, A., Symchowicz, S., and Taber, R.I. The effects of drugs inhibiting catecholamine uptake on tyramine and noradrenaline-induced contractions of the isolated rat vas deferens. Br. J. Pharmacol. 34(3), 484-492 (1968).
[4]. Farzin, D., Asghari, L., and Nowrouzi, M. Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. Pharmacol. Biochem. Behav. 72(3), 751-760 (2002).