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RepSox
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RepSox图片
CAS NO:446859-33-2
包装:10mg
市场价:10500元

产品名称
E-616452
SJN 2511
产品介绍
RepSox (E-616452) (GMP) 是 GMP 级别的 RepSox (HY-13012)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。RepSox 是一种有效的、选择性的 TGF-β-RI/ALK5 抑制剂。
生物活性

RepSox (E-616452) (GMP) is aRepSox(HY-13012) produced by using GMP guidelines.GMP small moleculesworks appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].

IC50& Target

IC50: ALK5 autophosphorylation (4 nM)

体外研究
(In Vitro)

RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs)[1].
RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs[2].
RepSox (GMP) together withForskolin(HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation[3].

分子量

287.32

性状

Solid

Formula

C17H13N5

CAS 号

446859-33-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)