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Androgen receptor-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Androgen receptor-IN-2图片
CAS NO:2416716-62-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Androgen receptor-IN-2 是一种有效的、具有口服活性的androgen receptor抑制剂。Androgen receptor-IN-2 对前列腺癌具有抗肿瘤活性。
生物活性

Androgen receptor-IN-2 is a potent and orally activeandrogen receptorinhibitor. Androgen receptor-IN-2 has antitumor activity against prostatecancer[1].

IC50& Target

Androgen receptor[1]

体外研究
(In Vitro)

Androgen receptor-IN-2 (compound A109, androgen-induced PSA-Luciferase assay) inhibits androgen binding to androgen receptor with an IC50of 535 nM[1].
Androgen receptor-IN-2 inhibits cell proliferation in LNCaP and LNCaP95 cells (IC50: 0.44 μM, 3.78 μM respectively)[1].
Androgen receptor-IN-2 shows a metabolic stability in liver microsome with a t1/2of more than 120 min, and in hepatocytes with a t1/2of more than 360 min[1].

体内研究
(In Vivo)

Androgen receptor-IN-2 (compound A109) (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors[1].
Androgen receptor-IN-2 (5 mg/kg, p.o., single dose, in male CD-1 mice) shows a t1/2of 8.1 h, Cmaxof 2673.3 ng/mL, F (%) of 33.6[1].

Animal Model:LNCaP Xenografts Model[1]
Dosage:60 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited tumor growth no obvious drug related toxicity (bodyweight change).
分子量

535.44

性状

Solid

Formula

C24H24Cl2N4O4S

CAS 号

2416716-62-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL(93.38 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.8676 mL9.3381 mL18.6762 mL
5 mM0.3735 mL1.8676 mL3.7352 mL
10 mM0.1868 mL0.9338 mL1.8676 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。