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(R)-(+)-Bay K 8644
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(R)-(+)-Bay K 8644图片
CAS NO:98791-67-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
(R)-(+)-Bay K 8644 是一种钙通道抑制剂。
Cas No.98791-67-4
化学名(R)-methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate
Canonical SMILESFC(F)(C1=CC=CC=C1[C@@H]2C(C(OC)=O)=C(C)NC(C)=C2[N+]([O-])=O)F
分子式C16H15F3N2O4
分子量356.3
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM).

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, Bay-K-8644 (R)-(+)- as an antagonist and S(-)-Bay K 8644 as an agonist. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). When Bay-K-8644 (R)-(+)- (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of Bay-K-8644 (R)-(+)- (0.5 μM), additional application of forskolin and sodium nitroprusside (SNP) further inhibits IBa[1]. Bay-K-8644 (R)-(+)- is a calcium channel inhibitor[2].

References:
[1]. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.
[2]. Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803.