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W-13 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
W-13 hydrochloride图片
CAS NO:88519-57-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍

calmodulin antagonist

Cas No.88519-57-7
别名N-(4-氨基丁基)-5-氯萘-2-磺酰胺盐酸盐
化学名N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride
Canonical SMILESClC1=CC=CC2=CC(S(=O)(NCCCCN)=O)=CC=C21.Cl
分子式C14H17ClN2O2S.HCl
分子量349.27
溶解度0.3mg/mL in ethanol, 14mg/mL in DMSO, 20mg/mL in DMF, 30mg/mL in water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.[1],[2],[3]

References
[1]. Katayama, N., Nishikawa, M., Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990).
[2]. Tebar, F., Villalonga, P., Sorkina, T., et al. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Molecular Biology of the Cell 13(6), 2057-2068 (2002).
[3]. Sengupta, P., Ruano, M.J., Tebar, F., et al. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: Dual effect of W-13 on epidermal growth factor receptor activation. The Journal of Biological Chemisty 282(11), 8474-8486 (2007).