D-Sorbitol (Sorbitol) 是一种六碳糖醇,可以用作糖的替代品。D-Sorbitol 可用作稳定的赋形剂和/或等渗剂,甜味剂,保湿剂,增稠剂和膳食补充剂。
生物活性 | D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1]. |
IC50& Target | Human Endogenous Metabolite |
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体外研究 (In Vitro) | Chemically, D-Sorbitol (Sorbitol) can be produced from glucose or sucrose, by hydrogenation at high temperature. D-Sorbitol (Sorbitol) can also be produced by bacteria such asZymomonas mobilisandCandida boidini, by an enzymatic process[1]. D-Sorbitol (Sorbitol) is used as a fast disintegrant in capsules and plasticizer in capsule shells and tablet film coatings. In oral liquids, D-Sorbitol (Sorbitol) is used as a sugar substitute and as a drug stabilizer. D-Sorbitol (Sorbitol) is also used as a solubility enhancer for drugs such as indomethacin. D-Sorbitol (Sorbitol) is commonly used as a stabilizing excipient and/or isotonicity agent in both liquid and lyophilized parenteral protein formulations. D-Sorbitol (Sorbitol) is used in topical formulations as a humectant[1].
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结构分类 | - Saccharides
- Monosaccharides
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Powder | -20°C | 3 years | | 4°C | 2 years | In solvent | -80°C | 6 months | | -20°C | 1 month |
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溶解性数据 | In Vitro: H2O : 100 mg/mL(548.94 mM;Need ultrasonic) DMSO : 100 mg/mL(548.94 mM;Need ultrasonic) 配制储备液 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL | 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL | 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百 分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶 1. 请依序添加每种溶剂: PBS Solubility: 110 mg/mL (603.83 mM); Clear solution; Need ultrasonic 2. 请依序添加每种溶剂: 10% DMSO 40%PEG300 5%Tween-80 45% saline Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (13.72 mM,饱和度未知) 的澄清溶液。 以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。 3. 请依序添加每种溶剂: 10% DMSO 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (13.72 mM,饱和度未知) 的澄清溶液。 以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。 4. 请依序添加每种溶剂: 10% DMSO 90%corn oil Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution
此方案可获得 ≥ 2.5 mg/mL (13.72 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。 以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。 *以上所有助溶剂都可在本网站选购。
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