Meropenem

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Meropenem

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

96036-03-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

美罗培南
SM 7338

产品介绍

Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素。Meropenem 对敏感和耐药的淋病奈瑟氏球菌 (MIC 值为 0.02-0.06 mg/mL)，流感嗜血杆菌 (MIC 值为 0.03-0.12 mg/mL) 和杜克氏杆菌 (MIC 值为 0.015-0.12 mg/mL) 具有活性。

生物活性

Meropenem (SM 7338) is a carbapenemantibioticwith broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistantN. gonorrhoeae(MIC value of 0.02-0.06 mg/mL),H. influenzae(MIC value of 0.03-0.12 mg/mL), andH. ducreyi(MIC value of 0.015-0.12 mg/mL)^[1]^[2].

体外研究
(In Vitro)

Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia^[2].

体内研究
(In Vivo)

Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection^[3].

Animal Model:	Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis^[3]
Dosage:	60 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly reduced the incidence of pancreatic infection.

Clinical Trial

分子量

383.46

Formula

C₁₇H₂₅N₃O₅S

CAS 号

96036-03-2

中文名称

美罗培南；美洛培南

结构分类

Antibiotics
Beta-lactam Antibiotics

来源

aerobes and anaerobes

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.