GnRH-I is a decapeptide of hypothalamic origin. GnRH-I acts primarily by regulating the release of biologically active follicle stimulating hormone (FSH) and luteinising hormone (LH) from the pituitary site mediated by theGnRH receptor(GnRHR)^[1][2].

GnRH-I (0.001-10 μM, 72 h) leads to a significant increase in cell proliferation of PMBC cell lines. Moreover, cells co-treated with IL-2 (50 U/mL) and GnRH-I exhibits a higher proliferative response than IL-2 treatment alone^[1].
GnRH-I (0.001-10 μM, 24 h) can effectively increase the expression of IL-2R mRNA of 162.3% compared to the control group in PMBCs^[1].
GnRH-I (10 nM, 3 h) can be expressed in human T cells and activates T cell production of laminin receptors while induces chemotaxis of normal human T cells to a key chemokine, stromal cell-derived factor-1α, through a lamina-coated filter^[2].
GnRH-I (10 nM, 72 h) significantly increases the migration of EL-4 t -lymphoma cells to the bone marrow and spleen of mice, but does not increase the migration of EL-4 to the thymus, kidney and liver, nor does it increase the number of EL-4 cells in plasma^[3].

1182.32

Solid

C₅₀H₇₅N₁₇O₁₃

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Pyr-HWSYGLRPG-NH2

• Others

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

H₂O : 50 mg/mL(42.29 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (84.58 mM); Clear solution; Need ultrasonic