NW 1028 is a potentVCP/p97inhibitor. NW 1028 targets the ND1L domain ofp97and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity withK_dvalues of 100 and 285 nM for ND1L and full lengthp97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells^[1].

NW1028 (0.1-10 μM) inhibits the ATPase activity of the D1 domain and do not impact the ATPase activity of the D2 domain^[1].
NW1028 (0.0001-100 μM; 72 h; HeLa K cells) does not cause cell death and does not activate the UPR response^[1].
NW1028 (10 μM; HeLa cells) affects the orientation of the mitotic spindle. NW1028 has a spindle orientation defect in the z axis with 53.9%, compared to 14.9% cells in control conditions^[1].

415.47

C₁₉H₂₁N₅O₄S

2749599-78-6

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