您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > S3QEL-2
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
S3QEL-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
S3QEL-2图片
CAS NO:890888-12-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
S3QEL-2 是线粒体复合物 III 产生超氧化物的抑制剂，有效且选择性地抑制位点 IIIQo 超氧化物的产生 (IC50=1.7 μM)。
Cas No.890888-12-7
化学名1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Canonical SMILESCCCN(CCC)C1=C(C=NN2C3=CC(C)=C(C)C=C3)C2=NC=N1
分子式C19H25N5
分子量323.4
溶解度10mg/mL in DMF, Slightly soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 &#181M) without altering normal bioenergetics function.[1] It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.

Reference:
[1]. Orr, A.L., Vargas, L., Turk, C.N., et al. Suppressors of superoxide production from mitochondrial complex III. Nat. Chem. Biol. 11, 834-840 (2015).