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PKSI-527
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PKSI-527图片
CAS NO:128837-71-8
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM).
Cas No.128837-71-8
Canonical SMILESNC[C@@H]1CC[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(NC3=CC=C(CC(O)=O)C=C3)=O)=O)CC1.Cl
分子式C25H31N3O4•HCl
分子量474
溶解度Water: 10 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of inflammatory cells in the tarsal joint of mice with collagen-induced arthritis.