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Pifithrin-β
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pifithrin-β图片
CAS NO:60477-34-1
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Pifithrin-β (PFT β) 是一种有效的 p53 抑制剂，IC50 为 23 μM。
Cas No.60477-34-1
别名5,6,7,8-四氢-2-(4-甲基苯基)-咪唑并[2,1-B]苯并噻唑,PFT β; Cyclic Pifithrin-α
化学名2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole
Canonical SMILESCC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2
分子式C16H16N2S
分子量268.38
溶解度DMF: 25 mg/ml,DMSO: 14 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

References:
[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.
[2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.
[3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.