CAS NO: | 69049-73-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Nedocromil suppresses the action or formation of multiple mediators, includinghistamine,leukotriene C4(LTC4), andprostaglandin D2(PGD2). | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Nedocromil inhibits the release of histamine, LTC4, and PGD2from mast cells challenged with antigen (with IC30values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 371.34 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H17NO7 | ||||||||||||||||
CAS 号 | 69049-73-6 | ||||||||||||||||
中文名称 | 奈多罗米 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 16.67 mg/mL(44.89 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |