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5α-hydroxy-6-keto Cholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5α-hydroxy-6-keto Cholesterol图片
CAS NO:13027-33-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
5α-hydroxy-6-keto Cholesterol 是 β-epoxide (5α,6β-epoxycholesterol) 在完整培养的人支气管上皮细胞 (16-HBE) 直接暴露于臭氧时的主要代谢物。
Cas No.13027-33-3
别名5α-羟基-6-酮胆固醇
Canonical SMILESO=C1[C@@]2(O)C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@@]([C@@](CC[C@]4([H])[C@H](C)CCCC(C)C)([H])[C@]4(C)CC3)([H])C1
分子式C27H46O3
分子量418.7
溶解度DMF: 20 mg/ml,DMSO: 0.5 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 5α-hydroxy-6-keto Cholesterol (6-oxo-3,5,-diol) is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor. Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates. 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range. Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type.