CAS NO: | 311309-27-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | RFRP-3 (Neuropeptide VF(124-131))(human), a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca2+ mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1]. | ||||||||||||||||
体外研究 (In Vitro) | RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1].Scatchard-plot analysis shows that125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kdvalue and the Bmaxvalues are 0.19 nM and 1.3 pM, respectively.RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1]. | ||||||||||||||||
分子量 | 969.14 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C45H72N14O10 | ||||||||||||||||
CAS 号 | 311309-27-0 | ||||||||||||||||
Sequence Shortening | VPNLPQRF-NH2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(103.18 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |