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RFRP-3(human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RFRP-3(human)图片
CAS NO:311309-27-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
Neuropeptide VF(124-131)(human)
产品介绍
RFRP-3 (Neuropeptide VF(124-131))(human),一种人GnIH 肽同源物,是一种促性腺激素分泌抑制 Ca2+动员的有效抑制剂。RFRP-3(human) 是一种NPFF1受体激动剂,它抑制 forskolin (HY-15371) 诱导的 cAMP 生成的 IC50值为 0.7 nM。
生物活性

RFRP-3 (Neuropeptide VF(124-131))(human), a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca2+ mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1].

体外研究
(In Vitro)

RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1].
Scatchard-plot analysis shows that125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kdvalue and the Bmaxvalues are 0.19 nM and 1.3 pM, respectively.
RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].
RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].

分子量

969.14

性状

Solid

Formula

C45H72N14O10

CAS 号

311309-27-0

Sequence Shortening

VPNLPQRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL(103.18 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.0318 mL5.1592 mL10.3184 mL
5 mM0.2064 mL1.0318 mL2.0637 mL
10 mM0.1032 mL0.5159 mL1.0318 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。