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[Leu5]-Enkephalin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
[Leu5]-Enkephalin图片
CAS NO:58822-25-6
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
Leu-enkephalin
Leucine enkephalin
Leucyl-enkephalin
产品介绍
[Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。
生物活性

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist atopioid receptors.

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG ofC. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].

分子量

555.62

性状

Solid

Formula

C28H37N5O7

CAS 号

58822-25-6

Sequence

Tyr-Gly-Gly-Phe-Leu

Sequence Shortening

YGGFL

中文名称

[Leu5]-脑啡肽

结构分类
  • Phenols
  • Monophenols
  • Others
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 150 mg/mL(269.97 mM)

H2O : 100 mg/mL(179.98 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.7998 mL8.9990 mL17.9979 mL
5 mM0.3600 mL1.7998 mL3.5996 mL
10 mM0.1800 mL0.8999 mL1.7998 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 6.67 mg/mL (12.00 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。