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Orexin A(human,rat,mouse)(TFA)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
10 mM * 1 mL in Water电议
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
Hypocretin-1 (human, rat, mouse) (TFA)
产品介绍
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA 是一种 33 氨基酸兴奋性神经肽，参与多种中枢和外周过程。Orexin A (human, rat, mouse) TFA 是一种特异性、高亲和力的 G 蛋白偶联受体OX1R激动剂，在调节摄食行为中起重要作用。Orexin A (human, rat, mouse) TFA 是一种有效的抗伤害和抗痛觉过敏的药物。
生物活性

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptorOX1R. Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2].

IC50& Target

OX1Receptor

 

体外研究
(In Vitro)

Orexin A (human, rat, mouse) TFA has high affinity for OX1R, with 38 nM IC50and 34 nM EC50values in the the [Ca2﹢]i transient assay[1].

体内研究
(In Vivo)

Orexin A (human, rat, mouse) TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively[2].
Orexin A (human, rat, mouse) TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].

Animal Model:Female mice (mouse carrageenan-induced thermal hyperalgesia test[2]
Dosage:3, 10 and 30 mg/kg
Administration:i.v.; 5 min pre-test
Result:Significantly increased the latency to response at 10 and 30 mg/kg.
分子量

3675.12

性状

Solid

Formula

C2HF3O2

Sequence Shortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(27.21 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.2721 mL1.3605 mL2.7210 mL
5 mM0.0544 mL0.2721 mL0.5442 mL
10 mM0.0272 mL0.1360 mL0.2721 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。