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Clopidogrel hydrogen sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clopidogrel hydrogen sulfate图片
CAS NO:120202-66-6
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
100mg电议
500mg电议
1 g电议
5 g电议

产品名称
硫酸氢氯吡格雷
(S)-(+)-Clopidogrel bisulfate
(S)-(+)-Clopidogrel hydrogen sulfate
产品介绍
Clopidogrel hydrogen sulfate 是一种抗血小板药物,可防止血栓形成。Clopidogrel hydrogen sulfate 抑制CYP2B6CYP2C19IC,sub>50分别为 18.2 nM 和 524 nM。 Clopidogrel hydrogen sulfate 是一种有效的抗血栓剂,可抑制 ADP 诱导的血小板聚集。Clopidogrel hydrogen sulfate 也是一种具有口服活性 P2Y(12) 抑制剂。
生物活性

Clopidogrel hydrogen sulfate is anantiplateletagent to prevent blood clots. Clopidogrel hydrogen sulfate inhibitsCYP2B6andCYP2C19withIC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2].Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].

IC50& Target[1]

CYP2B6

18.2 nM (IC50)

CYP2C19

524 nM (IC50)

体外研究
(In Vitro)

Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis[3].
Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis[3].

Western Blot Analysis[3]

Cell Line:GES-1 cells
Concentration:1.5 mM
Incubation Time:12 and 24 hours
Result:The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.
The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.

Apoptosis Analysis[3]

Cell Line:Gastric epithelial cell (GES-1) cells
Concentration:1.5 mM
Incubation Time:24 hours
Result:Induced apoptosis of gastric epithelial cells.
体内研究
(In Vivo)

Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel[4].

Animal Model:Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age[4]
Dosage:5 mg/kg
Administration:Gavage treatment
Result:Clopidogrel significantly inhibited thrombus formation compared with vehicle.
When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone.
In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.
Clinical Trial
分子量

419.90

性状

Solid

Formula

C16H18ClNO6S2

CAS 号

120202-66-6

中文名称

硫酸氢氯吡格雷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : ≥ 46.7 mg/mL(111.22 mM)

H2O : 16.67 mg/mL(39.70 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3815 mL11.9076 mL23.8152 mL
5 mM0.4763 mL2.3815 mL4.7630 mL
10 mM0.2382 mL1.1908 mL2.3815 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 50 mg/mL (119.08 mM); Clear solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20%SBE-β-CDin saline)

    Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.95 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90%corn oil

    Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.95 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在本网站选购。