四氢胡椒碱是胡椒碱的环己基类似物，是第一个来自长胡椒的天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 异构体 CYP1A1/芳烃羟化酶 (AHH; IC50=23 μM)。
| Cas No. | 23434-88-0 |
| 别名 | 四氢胡椒碱 |
| Canonical SMILES | O=C(CCCCC1=CC(OCO2)=C2C=C1)N3CCCCC3 |
| 分子式 | C17H23NO3 |
| 分子量 | 289.4 |
| 溶解度 | DMF: 10 mg/mL,DMSO: 10 mg/mL,DMSO:PBS (pH 7.2) (1:7): 0.1 mg/mL,Ethanol: 10 mg/mL |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tetrahydropiperine is a derivative of piperine and an arylpentanamide originally isolated from P. longum that has diverse biological activities. It is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 µM). It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 µM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 µM) in rat liver microsomes. Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 µl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR). Formulations containing tetrahydropiperine have been used to increase bioavailability of compounds applied to the skin. |
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