您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Abietic Acid
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Abietic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abietic Acid图片
CAS NO:514-10-3
包装与价格:
包装价格(元)
10g电议
25g电议
50g电议
100g电议

产品介绍
枞酸,一种从 Pimenta racemosa var 中分离出来的二萜。
Cas No.514-10-3
别名松香酸
Canonical SMILESCC(C)C1=CC2=CC[C@@]3([H])[C@](C)(C(O)=O)CCC[C@]3(C)[C@@]2([H])CC1
分子式C20H30O2
分子量302.5
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 20 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Abietic acid is an abietane diterpene originally isolated from wood resin that has diverse biological activities, including enzyme inhibitory, antiproliferative, antibacterial, and anti-obesity properties. It inhibits soybean 5-lipoxygenase (5-LO) and rat prostate testosterone 5α-reductase in cell-free assays (IC50s = 29.5 and 56 μM, respectively). Abietic acid selectively inhibits proliferation of HeLa cervical cancer cells over noncancerous Vero cells (IC50s = 15 and 53 μM, respectively) and inhibits the growth of S. epidermidis, P. acnes, and S. mitis bacteria (MICs = 8, 4, and 16 μg/ml, respectively). It induces expression of fatty acid binding protein 2 and lipoprotein lipase (LPL) in differentiated 3T3-L1 mouse adipocytes when used at a concentration of 25 μM. Abietic acid (40 mg/kg per day) also decreases body and adipose tissue weight in mice fed a high-fat diet.