γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis.
| Cas No. | 31450-14-3 |
| 别名 | γ-亚麻酸乙酯,Ethyl γ-linolenate |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\CCCCC(OCC)=O |
| 分子式 | C20H34O2 |
| 分子量 | 306.5 |
| 溶解度 | DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki value of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction. GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets. |
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