U-46619

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U-46619

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

56985-40-1

包装与价格：

包装	价格(元)
1mg (28.5 mM * 100 μL in Methyl acetate)	电议
5mg (28.5 mM * 500 μL in Methyl acetate)	电议

产品名称

9,11-Methanoepoxy PGH2

产品介绍

U-46619 (9,11-Methanoepoxy PGH2) 是一种稳定的血栓素 A2 (TXA2) 的类似物，也是一种有效的TXA2激动剂。

生物活性

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potentTXA2agonist^[1].

IC₅₀& Target

TXA2^[1]

体外研究
(In Vitro)

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC₅₀s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively^[1].
U-46619 (10 nM-10 μM) increases internal Ca²⁺concentration ([Ca²⁺]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency^[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets^[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways^[2].

体内研究
(In Vivo)

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)^[3].

Animal Model:	12-15 weeks-old male and female SHR^[2]
Dosage:	5 μg/kg
Administration:	Intravenous injection
Result:	Induceed a significant increase of MABP after 1 min in male SHR.

分子量

350.49

性状

Liquid

Formula

C₂₁H₃₄O₄

CAS 号

56985-40-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years