CAS NO: | 1036734-93-6 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | Teprotumumab is anIGF-1 receptor (IGF-1R)blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain ofIGF-1R. Teprotumumab inhibitsTSHand IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependentIL-6andIL-8expression andAktphosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1]. |
体外研究 (In Vitro) | Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours[1]. |
Clinical Trial | |
性状 | Liquid |
CAS 号 | 1036734-93-6 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |