您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > Selepressin
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Selepressin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Selepressin图片
CAS NO:876296-47-8
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
FE 202158
产品介绍
Selepressin (FE 202158) 是一种选择性的加压素 V1A受体 (vasopressin V1Areceptor) 激动剂。Selepressin 是一种有效的血管加压素。Selepressin 可用于脓毒性休克的研究。
生物活性

Selepressin (FE 202158) is a selectivevasopressin V1Areceptoragonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].

体外研究
(In Vitro)

Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3].

Western Blot Analysis[2]

Cell Line:HLMVECs
Concentration:1, 10, 100, 1000 nM
Incubation Time:24 h, 48 h
Result:Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.
体内研究
(In Vivo)

Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4].

Animal Model:LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Dosage:1 μg/kg/min
Administration:Left jugular vein infusion for 12 min
Result:Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.
Clinical Trial
分子量

1048.28

Formula

C46H73N13O11S2

CAS 号

876296-47-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.