[Asu1,6-Arg8]Vasopressin 是一种加压素 (vasopressin) 激动剂,可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环AMP积累和ACTH释放。
生物活性 | [Asu1,6-Arg8]Vasopressin is anvasopressinagonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture[1][2]. |
体外研究 (In Vitro) | [Asu1,6-Arg8]Vasopressin (100 nM; 0-240 分钟) 使 CRF 对培养的大鼠垂体前叶细胞 ACTH释放和循环 AMP 积累的刺激作用增加2倍。[Asu1,6-Arg8]Vasopressin 单独对腺垂体细胞中的循环AMP积累在任何时间间隔都没有影响[1]。
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Formula | |
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Sequence Shortening | YFQN-Asu-PRG-NH2 (Lactam:Tyr1-Asu5) |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
Solvent & Solubility | In Vitro: H2O Peptide Solubility and Storage Guidelines: 1. Calculate the length of the peptide. 2. Calculate the overall charge of the entire peptide according to the following table: | Contents | Assign value | Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 | Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 | Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution: Overall charge of peptide | Details | Negative (<0) | 1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. | Positive (>0) | 1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. | Zero (=0) | 1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
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