CAS NO: | 512784-93-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailablevasopressin 1a (V1a) receptorantagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64othersreceptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders[1]. | ||||||||||||||||
IC50& Target | Ki: 0.3 nM (human vasopressin 1a receptor)[1] | ||||||||||||||||
体内研究 (In Vivo) | SRX246 (2 mg/kg; i.v.) treatment shows that the Cmax, AUC0-∞and t1/2values are 953 ng/mL, 1141 ng ?h/mL, and 6.02 hours, respectively, in plasma pharmacokinetics. Following an oral administration (dose 20 mg/kg), The Cmax, AUC0-∞and t1/2values are 98.4 ng/mL, 624 ng ?h/mL and 2.38 hours, respectively[1].
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Clinical Trial | |||||||||||||||||
分子量 | 703.87 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C42H49N5O5 | ||||||||||||||||
CAS 号 | 512784-93-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(142.07 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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