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Roluperidone(CYR-101)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Roluperidone(CYR-101)图片
CAS NO:359625-79-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Roluperidone (CYR-101) (CYR-101) 是一种新型环状酰胺衍生物，对 5-HT2A 和 sigma-2 受体具有高度等效的亲和力（对 5-HT2A 和 sigma-2 的 Ki 分别为 7.53 nM 和 8.19 nM） .
Cas No.359625-79-9
别名CYR-101; MIN-101; MT-210
Canonical SMILESO=C1N(CC2CCN(CC(C3=CC=C(F)C=C3)=O)CC2)CC4=C1C=CC=C4
分子式C22H23FN2O2
分子量366.43
溶解度DMSO : 33.33 mg/mL (90.96 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).

Roluperidone (CYR-101) also shows binding affinity for α1-adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways, as well as in calcium neuronal modulation[1].

[1]. Davidson M, et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Jul 28:appiajp201717010122.