NDT-30805

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NDT-30805

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

NDT-30805 是一种选择性的NLRP3 inflammasome抑制剂。NDT-30805 是一种三唑吡啶酮衍生物，可抑制 PBMC 中 IL-1β的释放，其IC₅₀值为 0.013 μM。NDT-30805 可用于炎症和免疫的研究。

生物活性

NDT-30805 is a selectiveNLRP3inflammasomeinhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibitsIL-1βrelease in PBMCs with anIC₅₀of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity^[1].

IC₅₀& Target

NLRP3

NLRP3 inflammasome

体外研究
(In Vitro)

NDT-30805 (0-2 μM; 30 min) inhibits IL-1βrelease in PBMCs^[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells^[1].

Cell Viability Assay^[1]

Cell Line:	Human PBMCs
Concentration:	0-2 μM
Incubation Time:	30 min
Result:	Inhibited IL-1βrelease in PBMCs with an IC₅₀of 0.013 μM.

Cell Viability Assay^[1]

Cell Line:	THP1-ASC-GFP cells
Concentration:	0-2 μM
Incubation Time:	30 min
Result:	Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC₅₀of 0.034 μM.

分子量

414.53

Formula

C₂₃H₂₂N₆S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.