CPS-11 (N-(Hydroxymethyl)thalidomide) 是 Thalidomide (HY-14658) 类似物，是一种有效的抗癌剂 (anti-canceragent)。CPS-11 可抑制NF-κB，激活NFAT，通过升高ROS抑制细胞因子表达。CPS-11 对 MM (多发性骨髓瘤)细胞系表现出更广泛的活性谱和更高的效力。
| 生物活性 | CPS-11 (N-(Hydroxymethyl)thalidomide) aThalidomide(HY-14658) analogue, is a potentanti-canceragent. CPS-11 inhibitsNF-κB, activatesNFAT, and repress cytokine expression through elevatedROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3]. |
体外研究
(In Vitro) | CPS-11 abrogates ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells, confirming its ability to target tumor cells in the bone marrow microenvironment[1].
CPS-11 (0-200 μM, 0 or 4 h) shows virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27[2].
CPS-11 (0-100 μM, 24 or 48 h) was no toxic to H157 cells, WT MEFs or the p38α-/- MEFs at doses as high as 100 μM[2].
CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].
Western Blot Analysis[2] | Cell Line: | H157 cells, PC3 cells, HUVEC cells | | Concentration: | 0, 1, 5, 10, 20, 50, 100 and 200 μM | | Incubation Time: | 0, 15 min, 30 min, 1 h, 2 h, and 4 h | | Result: | Showed virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27. Increased Akt phosphorylation within 15 minutes, and decreased Akt phosphorylation from 15 minutes to 4 hours. |
Cell Cytotoxicity Assay[2] | Cell Line: | H157 cells, wild-type (WT) mouse embryonic fibroblasts (MEF) and p38α-/- MEF | | Concentration: | 0, 20, 50, and 100 μM | | Incubation Time: | 24 or 48 hours | | Result: | Showed no toxic to H157 cells at doses as high as 100 μM and an incubation time of 48 hours. had no toxic effect on either the WT MEFs or the p38α-/- MEFs at doses as high as 100 μM. |
Apoptosis Analysis[2] | Cell Line: | H157 cells | | Concentration: | 50 μM | | Incubation Time: | 24 or 48 hours | | Result: | Did not induce apoptosis in H157 cells at either time point. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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