| CAS NO: | 887375-26-0 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 887375-26-0 |
| 别名 | ZK-245186; BOL-303242X |
| Canonical SMILES | CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[C@@](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F |
| 分子式 | C25H26F4N2O2 |
| 分子量 | 462.48 |
| 溶解度 | DMSO : ≥ 50.6 mg/mL (109.41 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist. Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. Intradermal injection of compound 48/80 (50 ug in 50 uL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) and triamcinolone acetonide (0.015%) led to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. However, once daily topical administration of triamcinolone acetonide significantly reduced skin fold thickness from day 8 to 14, whereas no such reduction was observed for mapracorat. References: |
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