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Glucagon receptor antagonists-4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glucagon receptor antagonists-4图片
CAS NO:1393124-08-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
胰高血糖素受体拮抗剂-4 是一种高效、非肽和口服活性的胰高血糖素受体拮抗剂。
Cas No.1393124-08-7
别名Glucagon receptor antagonists-4
Canonical SMILESCCC[C@H](OC1=CC(C)=C(N2C=C(C(F)(F)F)C=N2)C(C)=C1)C3=CC=C(C(NCCC(O)=O)=O)C=C3
分子式C26H28F3N3O4
分子量503.51
溶解度DMSO : ≥ 30 mg/mL (59.58 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.

References:
[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.
[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.